Ministério da EducaçãoBrasil - Governo eletrônico

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Research Projects

The LACE's research line consists of investigating the acute, subacute and chronic effects of exercise on the cardiovascular system. The interest in this matter is due to the fact that exercise is extremely useful to assess the health of the cardiovascular system, because, during exercise, there is an increased demand on the cardiovascular system to maintain homeostasis (acute effect), and this demand continues hours after the cessation of exercise (subacute effect). An example of the increased demand is the behavior of heart rate. During rest, the heart rate of an young, healthy and sedentary is around 60 beats/min, whereas during exercise the heart rate can increase about 200%! Therefore, the observation of responses in the cardiovascular system during and after exercise exposes possible dysfunctions of the cardiovascular system that are not obvious at rest.

Another reason why LACE investigates the relationship between exercise and the cardiovascular system is due to the fact that cardiovascular diseases are the leading causes of death in the country and the training with exercise (chronic effect), one of the cheaper and more effective non-pharmacological means of prevention and treatment of diseases, mainly cardiovascular diseases.

The projects are funded by:

  • National Council for Scientific and Technological Development (CNPq);
  • Foundation for Research Support of Rio de Janeiro (FAPERJ);
  • Funder for Studies and Projects (FINEP);
  • Euclides da Cunha Foundation of Institutional Support to UFF (FEC);
  • Coordination of Improvement of Higher Education Personnel (CAPES).

Thus, the research projects currently under development at LACE are:


2010 - Present

Biochemical, cellular and genetic mechanisms of adaptation of the endothelial and autonomic function to physical activity and diet in subjects with cardiometabolic risk.

Description: The biochemical, cellular and genetic markers of the endothelial and autonomic function have been considered cardiometabolic risk factors and interventions such as physical training and diet appear to mitigate or to reverse these risk factors. Therefore, the objective of this project is to evaluate the biochemical profile (variables associated with cardiovascular diseases and inflammation), cell profile (cells related to the repair of the lining layer of blood vessels) and genetic profile (genetic inheritance, which passes from parents to children), as well as the response of these variables to maximal exercise test and physical training and diet in subjects with cardiometabolic risk.

2010 - Present

Impact of Exercise on Vascular Reactivity and Autonomic Nervous System in Patients with Cardiometabolic Risk.

Description: Exercise requires several vascular and autonomic responses to maintain cardiovascular homeostasis. Individuals with cardiometabolic risk tend to have vascular and autonomic dysfunction at rest. However these are more evident when evaluated under the influence of exercise. The objective of this project is to investigate the impact of exercise on vascular reactivity and autonomic function in individuals with cardiometabolic risk.

2009 - Present

Impact of counter-resistance exercise in individuals with untreated stage 1 hypertension: vascular reactivity and autonomic modulation.

Description: The cardiovascular system is strongly modulated by the autonomic nervous system. The cardiovascular autonomic assessment allows to draw a likely prognosis of cardiac patients and to diagnose dysautonomies, ie, differentiation between sympathetic, parasympathetic and mixed autonomic dysfunction. Currently we have several methods for autonomic assessment, such as battery of autonomic cardiovascular tests, assessment of cardiovascular reactivity to sensorial stress, assessment of the arterial baroreflex and the heart rate variability (HRV). The HRV analysis allows us to understand the spontaneous fluctuations that heart rate (HR) suffers over time. The sensitivity of arterial baroreflex may be determined by the degree of change in HR in response to changes in blood pressure.

2007 - Present

Impact of genetic polymorphisms in the magnitude of cardiovascular responses to acute and chronic exercise: vascular reactivity and autonomic modulation.

Description: phenotypic factors do not seem to fully explain the interindividual variation in cardiovascular responses to exercise. In this sense, several evidences suggest that genetic factors have a important role. The objective of this project is to investigate the impact of genetic polymorfisms in the magnitude of cardiovascular responses, particularly the responses of vascular reactivity and autonomic modulation to acute and chronic exercise.

2003 - Present

Impact of diet and exercise on endothelial and autonomic function of individuals at risk for type 2 diabetes.

Description: Individuals with a first-degree family history of type 2 diabetes are at high cardiometabolic risk, including an increased risk for developing type 2 diabetes. There is lack of evidence to identify whether the endothelial and autonomic dysfunction observed in individuals with first-degree family history of type 2 diabetes is a primary feature or a consequence of cardiometabolic risk, commonly observed in these individuals. The aim of this current project is to evaluate the effects of physical training and diet on vascular reactivity and autonomic modulation of individuals with a family history of type 2 DM.

1995 - Present

Effect of Cholinergic Stimulation with Pyridostigmine on the cardiovascular system.

Description: This project aims to study the cardiovascular effects of pyridostigmine bromide in healthy subjects and in subjetcs with coronary disease. Cholinergic stimulation with pyridostigmine bromide: assessment of cardiac output during the healthy subjects at rest, mental stress and isometric exercise.


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